Professor Toby Hughes
Position | Professor |
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Org Unit | Dental |
toby.hughes@adelaide.edu.au | |
Telephone | 831 33739 |
Location |
Floor/Room
3
,
Helen Mayo South
,
North Terrace
|
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Biography/ Background
My research focuses on the nexus between the genome, the epigenome, the environment and the microbiome. I have published widely, with more than 100 peer-reviewed publications, and an h-index of 30. I lead a small but productive group in projects spanning craniofacial development, dental anthropology, the oral microbiome, teeth as biomarkers of the prenatal environment, and speech development.
Current appointments and titles
Professor, Adelaide Dental School, The ÐÓ°ÉÖ±²¥ of Adelaide, ÐÓ°ÉÖ±²¥
Affiliate Professor, The ÐÓ°ÉÖ±²¥ of Sydney, ÐÓ°ÉÖ±²¥
Public Officer, International Association for Dental Research (ANZ Division)
Research funding
I have attracted research funding with a total value of more than AU$7M across all categories.
Recent invited presentations
2016 American Association of Physical Anthropology, Atlanta, Georgia
2017 ÐÓ°ÉÖ±²¥n Dental Therapists & Hygienists Associations, Adelaide, ÐÓ°ÉÖ±²¥
2018 ÐÓ°ÉÖ±²¥n Society of Orthodontists, Adelaide, ÐÓ°ÉÖ±²¥
2018 International Association of Dental Research, London, UK
Current membership of professional societies
International Federation of Dental Educators and Associations; American Association of Physical Anthropology; Dental Anthropology Association; ÐÓ°ÉÖ±²¥n Association of Human Biology; International Association of Dental Research; International Society of Twin Studies.
Board and committee membership
2012-2016 NHMRC Postdoctoral Reference Group
2021 ÐÓ°ÉÖ±²¥n Dental Board – General member applicant
Research supervision
BSciDent(Hons) - 24 students including 5 current (19 Completions, 65% 1st class, including 2 ÐÓ°ÉÖ±²¥ medals); several have gone on to complete PhDs with me.
GradDip(Forensic Odontology) – 4 students since 2008
HDR (PhD, DClinDent and Masters) in Dentistry – 16 students including 6 current (10 completions including 2 Dean’s Commendations and 1 ÐÓ°ÉÖ±²¥ Medal).
Manuscript and grant refereeing
I referee approximately 15 manuscripts per year for a range of leading international journals, including Journal of Dental Research (highest rating in discipline). I have been an external referee for grant organisations including the NIH; Singapore Ministry of Health; NHMRC; Channel 7 Children’s Research Foundation; ÐÓ°ÉÖ±²¥n Dental Research Foundation.
Current collaborations
Dr Christina Adler; U Sydney, AUS [Oral Microbiome]; Prof Manish Arora, Dr Christine Austin; Mt Sinai School of Medicine, USA [Pre-natal Exposome]; Prof Angela Morgan, MCRI, AUS [Speech Development]; Prof Jason Kovacic, Victor Chang CRI, AUS [Cardiovascular Risk Factors]; Prof Alan Brook; Queen Mary College, London, UK [Dental Development]; Prof Richard Scott, U Nevada, USA [Dental Anthropology]; Dr Kathleen Paul, U Arizona, USA [Dental Anthropology]; Prof Heather Edgar, U New Mexico, USA [Forensics and Dental Anthropology]
Recent organisation of conferences & symposia
2014 International Meeting on Methods in Oral Health Research, Adelaide, SA
2017 57th Annual Scientific Meeting of the IADR (ANZ division), Adelaide, SA
Research centre membership
NMHRC Centre for Clinical Research Excellence in Oral Health (2009-2013)
Centre for Orofacial Research and Learning, ÐÓ°ÉÖ±²¥ of Adelaide (2009-2017)
International Collaborating Network on Genetics of Orofacial Growth and Development (2007-2018)
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Qualifications
PhD (The ÐÓ°ÉÖ±²¥ of Adelaide) 2003
BAgSci (The ÐÓ°ÉÖ±²¥ of Adelaide) 1994 -
Research Interests
My research has a broad focus on early life factors that influence health and development throughout childhood and early adult life. I am interested in the nexus between oral and systemic conditions, and specifically in interactions between the genome, the epigenome, the environment and the commensal bacteria (the microbiome). Key current research areas include:
- The role of the oral microbiome in health and disease
- Speech development and the role of the oral anatomy
- Pre-natal influences on oral health in mid-childhood
- The role of diet in early development
- Craniofacial development in children
- Dental anthropology and forensics
My group has a broad range of projects available that enable students to tailor their experience to attain specific skills. We operate both wet and dry laboratories, have a strong track record in bioinformatics and big data analysis, and have some very active collaborations with other groups (and potential co-supervisors) in Sydney, Melbourne and the USA.
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Publications
Refereed book chapters
Hughes T , Townsend G 2013. Twin and family studies of human dental crown morphology: genetic, epigenetic and environmental determinants of the modern human dentition. In: Anthropological Perspectives on Tooth Morphology, eds Scott GR, Irish J, Cambridge, Cambridge ÐÓ°ÉÖ±²¥ Press.
Ashar A, Hughes T, James H, Kaidonis J, Khamis F, Townsend G 2012 Dental crown and arch size in Europeans and ÐÓ°ÉÖ±²¥n Aboriginals. In: New Directions in Dental Anthropology, eds Townsend G, Kanazawa E, Takayama H, Adelaide, ÐÓ°ÉÖ±²¥ of Adelaide Press, pp 65-80.
Chan E, Bockmann M, Hughes T, Mihailidis S, Townsend G 2012. Do feeding practices, gestation length, and birth weight affect the timing of emergence of the first primary tooth? In: New Directions in Dental Anthropology, eds Townsend G, Kanazawa E, Takayama H, Adelaide, ÐÓ°ÉÖ±²¥ of Adelaide Press, pp 35-45.
Hughes T, Townsend G 2012. Genes for teeth - drawing inference from family data. In: New Directions in Dental Anthropology, eds Townsend G, Kanazawa E, Takayama H, Adelaide, ÐÓ°ÉÖ±²¥ of Adelaide Press, pp 22-34.
Ribeiro D, Sampson W, Hughes T, Brook A, Townsend G 2012. Sexual dimorphism in the primary and permanent dentitions of twins: an approach to clarifying the role of hormonal factors. In: New Directions in Dental Anthropology, eds Townsend G, Kanazawa E, Takayama H, Adelaide, ÐÓ°ÉÖ±²¥ of Adelaide Press, pp 46-64.
Townsend G, Bockmann M, Hughes T, Mihailidis S, Seow WK, Brook A 2012. New approaches to dental anthropology based on the study of twins. In: New Directions in Dental Anthropology, eds Townsend G, Kanazawa E, Takayama H, Adelaide, ÐÓ°ÉÖ±²¥ of Adelaide Press, pp 10-21.
Mihailidis S, Woodroffe S, Hughes T, Bockmann M, Townsend G 2009. Patterns of asymmetry in primary tooth emergence of ÐÓ°ÉÖ±²¥n twins. In: Comparative Dental Morphology, eds Koppe T, Meyer G, Alt KW, Frontiers in Oral. Biology, Basel, Karger, vol 13, pp 110-115.
Townsend G, Hughes T, Bockmann M, Smith R, Brook A 2009 How studies of twins can inform our understanding of dental morphology. In: Comparative Dental Morphology, eds Koppe T, Meyer G, Alt KW, Frontiers in Oral Biology, Basel, Karger, 2009, 13:136-141.
Refereed journal article
Brook A, Hone A, Gallo I, Brook O'Donnell M, Riolo R, Townsend G, Hughes T, Hart E 2013. General and craniofacial development are complex adaptive processes influenced by diversity. Aust. Dent. J. (special issue, in press, accepted January 2013).
Brook A, Jernvall J, Smith R, Chen K, Hone A, Hart E, Gallo I, Hughes T, Townsend G 2013. The dentition: the outcomes of morphogenesis leading to variations of tooth number, size and shape. Aust. Dent. J. (special issue, in press, accepted January 2013).
Hughes T, Seow K, Bockmann M, Mihaildis S, Lekkas D, Ranjitkar S, Pinkerton S, Brook A, Townsend G 2013. The teeth and faces of twins: providing insights into dento-facial development and oral health for practicing oral health professionals. Aust. Dent. J. (special issue, in press, accepted January 2013).
Mihaildis S, Ashar A, Hughes T, Bockmann M, Brook A and Townsend G 2013. Dental phenomics: similarities and differences in monozygotic twins. Dental Tribune
McConnell E, Bockmann M, Hughes T, Mihailidis S and Townsend G 2013. The influence of chorion type on emergence of the first primary tooth in ÐÓ°ÉÖ±²¥n twins. Twin Research and Human Genetics (under revision).
Ribeiro D, Brook A, Hughes T [30%], Sampson W, Townsend G 2013. Tooth crown size in opposite sex twins: role of intrauterine male hormones. Journal of Dental Research (in press, accepted 6th March 2013).
Williams S, Hughes T, Townsend G 2013. TITLE Aust. Dent. J. (special issue, in press, accepted January 2013).
Hughes T, Bockmann M, Milhailidis S, Bennett C, Harris A, Seow WK, Lekkas D, Ranjitkar S, Rupinskas L, Pinkerton S, Brook A, Townsend GC 2012. Genetic, epigenetic, and environmental influences on dentofacial ÐÓ°ÉÖ±²¥ and oral health: ongoing studies of ÐÓ°ÉÖ±²¥n twins and their families. Twin Research and Human Genetics 16(S1):43-51. .
ten Berge F, te Poel J, Ranjitkar S, Kaidonis J, Lobbezoo F, Hughes T, Townsend G 2012. Determining the direction of tooth grinding: an in vitro study. Journal of Oral Rehabilitation 39(8):576-583. .
Bockmann M, Harris A, Bennett C, Odeh R, Hughes T, Townsend G 2011. Timing of colonization of caries-producing bacteria: an approach based on studying monozygotic twin pairs. International Journal of Dentistry 2011:571573, 7 pages. .
Higgins D, Kaidonis J, Austin J, Townsend G, James H, Hughes T 2011. Dentine and cementum as sources of nuclear DNA for use in human identification. ÐÓ°ÉÖ±²¥n Journal of Forensic Science 43:287-295. .
Townsend G, Bockmann M, Hughes T [25%], Brook A 2011. Genetic, environmental and epigenetic influences on variation in human tooth number, size and shape. Odontology 100(1):1-9 .
Bockmann M, Hughes T, Townsend G 2010. Genetic modelling of primary tooth emergence: a study of ÐÓ°ÉÖ±²¥n twins. Twin Research and Human Genetics 13:573-581. .
Woodroffe S, Mihailidis S, Hughes T, Bockmann M, Seow W, Gotjamanos T, Townsend G 2010. Primary tooth emergence in ÐÓ°ÉÖ±²¥n twins: timing, sequence and patterns of asymmetry. ÐÓ°ÉÖ±²¥n Dental Journal 55:245-251. .
Higgins D, Hughes T, James H, Townsend G 2009. Strong genetic influence on hypocone expression of permanent maxillary molars in South ÐÓ°ÉÖ±²¥n twins. Dental Anthropology 22:1-7.
Kunchur R, Need A, Hughes T, Goss A 2009. A clinical investigation of the CTX test in the prevention and management of bisphosphonate associated ONJ. Journal of Oral and Maxillofacial Surgery 67(6):1167-1173 .
Lau E, Sampson W, Townsend G, Hughes T 2009. An evaluation of maxillary and mandibular rotational responses with the Clark twin block appliance. ÐÓ°ÉÖ±²¥n Orthodontic Journal 25:48-58.
Ranjitkar S, Naryana T, Kaidonis J, Hughes T, Richards L, Townsend G 2009. The effect of casein phosphopeptide-amorphous calcium phosphate on erosive dentine wear. ÐÓ°ÉÖ±²¥n Dental Journal 54(2):101-107
Townsend G, Hughes T, Luciano M, Bockmann M, Brook A 2009 Genetic and environmental influences on human dental variation: A critical evaluation of studies involving twins. Archives of Oral Biology 54(S1):S45-S51. .
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Professional Associations
International Association of Dental Research; International Society of Twin Studies; American Association of Physical Anthropology; ÐÓ°ÉÖ±²¥n Association of Human Biology; ÐÓ°ÉÖ±²¥n Society of Medical Researchers
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Professional Interests
Genetics
Human Genetics
Dental Genetics
Craniofacial Growth & Development
Oral Health
Structural Equation Modelling
Twins
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Entry last updated: Monday, 9 May 2022
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